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- how could microbiomes have such immense influences on a person?
The makeup of our microbiomes-the unique communities of bacteria, viruses and other microbes that live in and on us-have been linked, with varying degrees of evidence, to everything from inflammatory bowel disease to athletic performance.But exactly how could such tiny organisms have such immense influences on a person?University of California San Diego researchers have created the first-ever map of all the molecules in every organ of a mouse and the ways in which they are modified by microbes. In one surprising example, they discovered that microbes control the structure of bile acids in both mice and people. Journal of Advanced Emergency Medicine has similar research, Advanced Emergency Medicine is an international, Open Access, peer reviewed journal, which publishes information relevant to the practice, educational advancements, and investigation of emergency medicine. The journal aims to advance the science, education, and clinical practice of emergency medicine, to serve as a voice for the academic emergency medicine community, and help physicians and medical personnel improve patient care by providing the opportunity to access and learn about the most current research in emergency medicine. AEM contains research papers and clinical studies as well as articles focusing on the training of emergency physicians and on the practice of emergency medicine.For more information, please visit:http://aem.usp-pl.com/index.php/aem
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- Relieve pain? Magnet-controlled bioelectronic implant may work
A team of Rice University engineers has introduced the first neural implant that can be both programmed and charged remotely with a magnetic field. Their breakthrough may make possible imbedded devices like a spinal cord-stimulating unit with a battery-powered magnetic transmitter on a wearable belt. The integrated microsystem, called MagNI (for magnetoelectric neural implant), incorporates magnetoelectric transducers. These allow the chip to harvest power from an alternating magnetic field outside the body. The system was developed by Kaiyuan Yang, an assistant professor of electrical and computer engineering.Electronic technology is increasingly used in life, Electronics Science Technology and Application is an international scientific journal in the field of Electrical and Electronic Engineering and in related disciplines which is aims to provide a high profile, leading edge forum for academic researchers, industrial professionals, engineers, consultants, managers, educators and policy makers working in the field to contribute and disseminate innovative new work on Electronics and Electrical Engineering.For more information, please visit:http://esta.usp-pl.com/index.php/esta
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- estrogen-Estrogen Receptor-Hif2AlphaThe presence of pathway may be in condylar cartilageOA Plays an important role in the occurrence and developmen
TMD refers to the temporom and ibular joint (TMJ) or a common oral disease of the masticatory muscles.Joint Noise Wait.In vitro culture of mandibular condylar chondrocytes high concentration (10-6.Mol/L)Estrogen can inhibit the proliferation of chondrocytes and the synthesis of proteoglycan. Excessive genistein (a phytoestrogen) could induce Col,Aggrecan and proliferating cell nuclear antigen (PCNA)Significantly down-regulated the expression the stimulation of estrogen can aggrecan and Col of MRNa expression levels were significantly reduced, while Promoting inflammatory FactorsIl-1,TNF-Alpha and matrix degradation factorMmp13OfMRNaUp-regulated expression. All the above results suggest that high concentrations of estrogen can induce the cartilage of condylar chondrocyte Other studies show that,ERAlphaIt participates in the Proliferation Effect of hypoxia on breast cancer stem cells ERAl pha Antagonist Resistance Collaboration relationship. In order to Investigate the hypoxia induced factor2α(HIF2α) In estrogen stimulation under the mandibular condylar cartilage cells effect in role ,Tao Hui made a study on hypoxia induced factor 2α and the study results was published on the journal of Probe-Dentistry . The results showed that high concentrations of estrogen could significantly up-regulate the degeneration of condylar chondrocytes.Hif2Alpha and its downstream factor Mmp13,VEGF,ColProtein Expression Level.The results are consistent with previous reportsOACartilage TissueHif2Alpha,the results further confirmed that high concentrations of estrogen could be directly up-regulated.Hif2AlphaUp-regulation of its downstream factor expression can accelerate the process of chondrocyte degeneration.We also found that estrogen receptor blockers andHif2AlphaBlocking Agents can reverse estrogen-induced Hif2Alpha Up-regulation of downstream Factor Expression,Cartilage Matrix Synthesis reduction and other effects.According to the analysis, estrogen-Estrogen Receptor-Hif2AlphaThe presence of pathway may be incondylar cartilageOA Plays an important role in the occurrence and development. For more information, please visit:http://probe.usp-pl.com/index.php/DEN/article/view/1192